MDMA for PTSD

Researchers have been investigating the therapeutic potential of MDMA in treating post-traumatic stress disorder (PTSD). Traditional treatments for PTSD, such as psychotherapy and medication, may not always be effective for everyone, leading researchers to explore alternative therapies. MDMA has shown significant promise in the treatment of PTSD.

Studies Exploring MDMA for PTSD

Below are excerpts from studies that look at how MDMA can assist with PTSD treatment.

3,4-Methylenedioxymethamphetamine facilitates fear extinction learning

“These findings suggest that MDMA enhances fear memory extinction through a BDNF-dependent mechanism, and that MDMA may be a useful adjunct to exposure-based therapies for PTSD and other anxiety disorders characterized by altered fear learning.”

MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial

“MDMA holds promise as a facilitator of CBCT to achieve more robust and broad effects on individual and relational functioning in those with PTSD and their partners.”

Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder: A systematic review and meta-analysis

“MDMA-assisted psychotherapy appears to be a potentially safe, effective, and durable treatment for individuals with chronic, treatment-refractory PTSD.”

Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study

“It was promising that we found the majority of these subjects with previously severe PTSD who were unresponsive to existing treatments had symptomatic relief provided by MDMA-assisted psychotherapy that persisted over time, with no subjects reporting harm from participation in the study.”

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

“These data indicate that, compared with manualized therapy with inactive placebo, MDMA-assisted therapy is highly efficacious in individuals with severe PTSD, and treatment is safe and well-tolerated, even in those with comorbidities.”